Publications

KI Research Institute Impact Report, June 2024

KI Research Institute was established as non-profit research institute with the aim to promote positive impact on public health. Our vision is to promote data-driven healthcare by leading state-of-the-art research in computational health and delivering its insights and tools to decision-makers in healthcare organizations and government agencies. This is our first report, describing the work that we do and several selected projects that created impact in their field. We look forward to making this a frequent update on our efforts and impactful solutions.

Sex-Specific Developmental Scales for Surveillance

Tamar Sudry, Guy Amit, Deena R Zimmerman, Meytal Avgil Tsadok, Ravit Baruch, Hadar Yardeni, Pinchas Akiva, Dror Ben Moshe, Eitan Bachmat,Yair Sadaka

Early Prediction of Autistic Spectrum Disorder Using Developmental Surveillance Data

Guy Amit, Yonatan Bilu, Tamar Sudry, Meytal Avgil Tsadok, Deena R. Zimmerman, Ravit Baruch, Nitsa Kasir, Pinchas Akiva, Yair Sadaka

A Developmental Surveillance Score for Quantitative Monitoring of Early Childhood Milestone Attainment: Algorithm Development and Validation

Yonatan Bilu, Guy Amit, Tamar Sudry, Pinchas Akiva, Meytal Avgil Tsadok, Deena R. Zimmerman, Ravit Baruch, Yair Sadaka

Youth Mental Health Outcomes up to Two Years After SARS-CoV-2 Infection Long-COVID or Long-Pandemic Syndrome: A Retrospective Cohort Study

Yonatan Bilu PhD¹, Natalie Flaks-Manov PhD^1*, Inbal Goldshtein¹, Maytal Bivas-Benita PhD¹, Pinchas Akiva PhD¹, Gilad Bodenheimer MD² and Shira Greenfeld MD²

Predicting future onset of depression among middle-aged adults with no psychiatric history

Yonatan Bilu, PhD,  Nir Kalkstein, BSc, Eva Gilboa-Schechtman,  Pinchas Akiva, PhD, Gil Zalsman, Liat Itzhaky and Dana Atzil-slonim

Data-Driven Assessment of Adolescents’ Mental Health During the COVID-19 Pandemic

Yonatan Bilu, PhD, Natalie Flaks-Manov, PhD, Maytal Bivas-Benita, PhD, Pinchas Akiva, PhD, Nir Kalkstein, BSc, Yoav Yehezkelli, MD, MHA, Miri Mizrahi-Reuveni, MD, Anat Ekka-Zohar, PhD, Shirley Shapiro Ben David, MD, Uri Lerner, PhD, Gilad Bodenheimer, MD, Shira Greenfeld, MD.

Israeli child development report

The report describing trends of developmental milestone attainment in Israeli children is based on 1,002,700 children ages birth until 6 years with 4,441,689 developmental visits between the years 2016 and 2020. It shows national trends of child development in the gross motor, fine motor, language and social domains, and could highlight subgroups in need for intervention. Annual report of these trends may also help assess the effectiveness of intervention programs in an attempt to maximize the developmental potential of children in Israel.

A preprint can be found here.

Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study

Barak Mizrahi, MSc, Tamar Sudry, MD, Natalie Flaks-Manov, PhD, Yoav Yehezkelli, BSc, Nir Kalkstein, BSc, Pinchas Akiva,PhD, Anat Ekka-Zohar ,PhD, Shirley Shapiro Ben David ,MD, Uri Lerner ,PhD, Maytal Bivas-Benita PhD  and Shira Greenfeld MD

BMJ 2023; 380

Assessing the Attainment Rates of Updated CDC Milestones Using a New Israeli Developmental Scale

Yair Sadaka, MD, PhD, MHA, Tamar Sudry, MD, Deena R. Zimmerman, MD, MPH, Meytal Avgil Tsadok, PhD, Ravit Baruch, RN, MA, Hadar Yardeni, MD, Dror Ben Moshe, BSc, Pinchas Akiva, PhD, Guy Amit, PhD

PEDIATRICS Volume 150, number 6, December 2022:e2022057499

The Israeli developmental scale for ages 0-5 years

The Israeli developmental scale is based on over 3.5 million developmental examinations performed on approximately 650,000 children in Israel between the years 2014-2020. It was developed by a collaborative research team from KI research Institute, the Ministry of Health  and the TIMNA – the big data platform of the Israeli MOH.

Estimating Model Performance on External Samples from Their Limited Statistical Characteristics

Tal El-Hay, Chen Yanover

Proceedings of the Conference on Health, Inference, and Learning, PMLR 174:48-62, 2022.

Developmental Milestone Attainment of Israeli Children During the COVID-19 Pandemic

Guy Amit, Tamar Sudry, Pinchas Akiva, Meytal Avgil Tsadok,Deena Zimmerman, Yair Sadaka

The 14th Annual Health Policy Conference,

March 30, 2022

Data-driven assessment of Israeli adolescents’ mental health during the COVID-19 pandemic

Yonatan Bilu, Natalie Flaks-Manov, Maytal Bivas-Benita, Pinchas Akiva, Nir Kalkstein, Yoav Yehezkelli, Miri Mizrahi-Reuveni, Anat Ekka-Zohar, Shirley Shapiro Ben David, Uri Lerner, Gilad Bodenheimer and Shira Greenfeld

The 14th Annual Health Policy Conference,

March 30, 2022

Standardization of a Developmental Milestone Scale Using Data From Children in Israel

Tamar Sudry, MD; Deena R. Zimmerman, MD, MPH; Hadar Yardeni, MD; Adina Joseph, MD; Ravit Baruch, RN, MA; Itamar Grotto,MD, MPH, PhD; Dan Greenberg, MSc, PhD; Roni Eilenberg, MSc; Guy Amit, PhD; Pinchas Akiva, PhD; Meytal Avgil Tsadok, PhD; Yitzhak Rize, PhD; Hani Zaworbach, BSc; Moshe Uziel, BSc; Dror Ben Moshe, BSc; Irit Lior Sadaka, RN, MPH; Eitan Bachmat, PhD; Judah Freedman, MPH; Yair Sadaka, MD, PhD, MHA

JAMA Network Open. 2022;5(3):e222184. doi:10.1001/jamanetworkopen.2022.2184

Mental health assessment of Israeli adolescents before and during the COVID-19 pandemic

Yonatan Bilu, Natalie Flaks-Manov, Maytal Bivas-Benita, Pinchas Akiva, Nir Kalkstein, Yoav Yehezkelli, Miri Mizrahi-Reuveni, Anat Aka-Zohar, Shirley Shapiro Ben David, Uri Lerner, Gilad Bodenheimer, Shira Greenfeld

medRxiv 2022.01.06.22268809; doi: https://doi.org/10.1101/2022.01.06.22268809

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

Yinon M Bar-On, Yair Goldberg, Micha Mandel, Omri Bodenheimer, Laurence Freedman, Nir Kalkstein, Barak Mizrahi, Sharon Alroy-Preis, Nachman Ash, Ron Milo , Amit Huppert 

N Engl J Med. 2021 Sep 15. doi: 10.1056/NEJMoa2114255

Estimation of postpartum depression risk from electronic health records using machine learning

Guy Amit, Irena Girshovitz, Karni Marcus, Yiye Zhang, Jyotishman Pathak, Vered Bar and Pinchas Akiva

BMC Pregnancy and Childbirth (2021) 21:630; doi:10.1186/s12884-021-04087-8

Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine

Barak Mizrahi, Roni Lotan, Nir Kalkstein, Asaf Peretz, Galit Perez, Amir Ben-Tov, Gabriel Chodick, Sivan Gazit, Tal Patalon

Nat Commun. 2021 Nov 4;12(1):6379. doi: 10.1038/s41467-021-26672-3. PMID: 34737312

BNT162b2 mRNA Vaccine Effectiveness Given Confirmed Exposure: Analysis of Household Members of COVID-19 Patients

Sivan Gazit, Barak Mizrahi, Nir Kalkstein, Ami Neuberger, Asaf Peretz, Miri Mizrahi-Reuveni, Tal Patalon

Clin Infect Dis. 2021 Nov 24:ciab973. doi: 10.1093/cid/ciab973. Online ahead of print. PMID: 34849630

Developmental Milestone Attainment of Israeli Children During the COVID-19 Pandemic

Guy Amit, Tamar Sudry, Pinchas Akiva, Meytal Avgil Tsadok,Deena Zimmerman, Yair Sadaka

The 14th Annual Health Policy Conference,

March 30, 2022

Data-driven assessment of Israeli adolescents’ mental health during the COVID-19 pandemic

Yonatan Bilu, Natalie Flaks-Manov, Maytal Bivas-Benita, Pinchas Akiva, Nir Kalkstein, Yoav Yehezkelli, Miri Mizrahi-Reuveni, Anat Ekka-Zohar, Shirley Shapiro Ben David, Uri Lerner, Gilad Bodenheimer and Shira Greenfeld

The 14th Annual Health Policy Conference,

March 30, 2022

Results of an early second PCR test performed on SARS-CoV-2 positive patients may support risk assessment for severe COVID-19

Barak Mizrahi, Maytal Bivas-Benita, Nir Kalkstein, Pinchas Akiva, Chen Yanover, Yoav Yehezkelli, Yoav Kessler, Sharon Hermoni Alon, Eitan Rubin, Gabriel Chodick.

Sci Rep. 2021 Oct 14;11(1):20463. doi: 10.1038/s41598-021-99671-5.PMID: 34650138

Dynamics of COVID-19 – paper published in nature comm.

Mizrahi B, Shilo S, Rossman H, Kalkstein N, Marcus K, Barer Y, Keshet A, Shamir-Stein N, Shalev V, Zohar AE, Chodick G, Segal E.

Nat Commun. 2020 Dec 4;11(1):6208. doi: 10.1038/s41467-020-20053-y.

Enhancing the detection of postpartum depression from electronic health records using machine learning algorithms

28th European Congress of Psychiatry
4-7 July 2020

Guy Amit, PhD

What factors increase the risk of complications in SARS-Cov-2 infected patients? A cohort study in a nationwide Israeli health organization

Yanover C, Mizrahi B, Kalkstein N, Marcus K, Akiva P, Barer Y, Shalev V, Chodick G.

JMIR Public Health Surveill. 2020 Aug 25;6(3):e20872. doi: 10.2196/20872.